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Huamn Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2)

  • Serial No. GA-P0032HU
    Species Human
    Specification 0.1 mg/0.2mg
    Brand GenAsia
    Origin Shanghai
    Price US$350/US$620
    Detailed information
    1 Host: Escherichia coli (E. coli)
    2 Species: Human
    3 Protein Type: Recombinant
    4 Synonyms: CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57, ICH-1, Nedd2, Caspase-2, ICH-1L/1S, ICH1L1S, xCaspase-2
    5 Purity: 95% by SDS-PAGE
    6 Application: WB、 Elisa、 Functional Studies
    7 Background:
    Caspase-2 (also know as Ich-1, Nedd-2) is a member of the caspase-family of cysteine proteases. Similar to other caspases, caspase-2 also exists in cells as an inactive proenzyme. During apoptosis pro-caspase-2 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases. The processed active caspase-2 is a heterotetramer consisting of two large (19 kDa) and two small (12 kDa) subunits.The recombinant active human caspase-2 was expressed in E. coli. The active caspase-2 preferentially cleaves caspase-2 substrates (e.g., VDVAD-AFC or VDVAD-pNA) and is routinely tested for its ability to enzymatically cleave these two substrates Ac-VDVAD-pNA or Ac-VDVAD-AFC (ABIN412387). 
    8 Storage&Stability:
    Avoid repeated freeze and thaw cycle.Store at 2-8℃ for delivery and store at -20 or -70℃ for future use. The loss rate of the target protein which describes the stability was determined by accelerated thermal degradation test.That is to incubate the protein at 37℃ for 48h and no obvious degradation and precipitation were observed.The loss of this protein is less than 5% within the expiration date under appropriate storage condition.