1 Host: Escherichia coli (E. coli)
2 Species: Human
3 Protein Type: Recombinant
4 Synonyms: OP-1, OP1, bmp7, fb83f09, wu:fb83f09, BMP-7, bmp-7, op-1, BMP7, zgc:153025
5 Purity: 95% by SDS-PAGE
6 Application: WB、 Elisa、 Functional Studies
7 Background:
The bone morphogenetic proteins are a family of secreted signalling molecules that can induce ectopic bone growth. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Bone morphogenetic protein 7 (BMP-7), also known as osteogenic protein 1 (OP1), is a widely expressed TGFb superfamily member with important functions during embryogenesis, in the adult, and in disease (Chen et al., 2004, Kishigami and Mishina 2005). BMP-7 plays a role in a variety of organ systems. It promotes new bone formation and nephron development (Sampath et al., 1992, Kazama et al., 2008), inhibits the branching of prostate epithelium (Grishina et al., 2005), and antagonizes epithelialmesenchymal transition (Zeisberg et al., 2003, Yu et al., 2009).
8 Storage&Stability：
Avoid repeated freeze and thaw cycle.Store at 2-8℃ for delivery and store at -20 or -70℃ for future use. The loss rate of the target protein which describes the stability was determined by accelerated thermal degradation test.That is to incubate the protein at 37℃ for 48h and no obvious degradation and precipitation were observed.The loss of this protein is less than 5% within the expiration date under appropriate storage condition.