1 Host: Escherichia coli (E. coli)
2 Species: Human
3 Protein Type: Recombinant
4 Synonyms: Il12, IL-12B, IL-12p40, IL12p40
5 Purity: 95% by SDS-PAGE
6 Application: WB、 Elisa、 Functional Studies
7 Background:
Interleukin-12 (IL-12) is a heterodimer cytokine composed of p40 and p35 subunits. It is mainly produced by macrophages, dendritic cells, and B cells. It has multiple effects on T and natural killer (NK) cells. In particular it appears to be a major factor for the development of cellular immunity. IL-12 stimulates the production and secretion of several cytokines, in particular IFN-gamma, by NK cells and T cells, induces proliferation and enhances the cytotoxic activity within these cell populations. The p40 subunit of IL-12 interacts with the beta subunit of IL-12R and the disulfide linked p40 homodimer specifically antagonize the activity of bioactive IL-12 in different assay systems.
8 Storage&Stability：
Avoid repeated freeze and thaw cycle.Store at 2-8℃ for delivery and store at -20 or -70℃ for future use. The loss rate of the target protein which describes the stability was determined by accelerated thermal degradation test.That is to incubate the protein at 37℃ for 48h and no obvious degradation and precipitation were observed.The loss of this protein is less than 5% within the expiration date under appropriate storage condition.